质谱流式技术应用
质谱流式细胞技术（Mass Cytometry, CyTOF）已被应用到众多世界前沿的医学研究中，涉及疾病领域涵盖了肿瘤、血液病、心脑血管疾病、神经系统疾病、自身免疫病、感染、妇科疾病等多个领域，研究领域涉及新靶点发现、个性化治疗、药物研发、精准诊断、疾病机理研究等多个方向。
质谱流式细胞技术近三年高分文章集锦
1.Goswami, S. et al. Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma. Nat. Med. 2020.
2.Huhn, O. et al. Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy. Nat. Commun. 2020.
3.Gate, D. et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature. 2020.
4.Chiu D. et al. Hepatocellular Carcinoma Cells Upregulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice. Gastroenterology. 2020.
5.Zhang, F. et al. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat. Immunol. 2019.
6.Zhang, Q. et al. Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas. Gut. 2019.
7.Alpert, A. et al. A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring. Nat. Med., 2019.
8.Li, N. et al. Memory CD4+ T cells are generated in the human fetal intestine. Nat. Immunol., 2019.
9.Giordani, L. et al. High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations. Mol. Cell. 2019. Menzies, A. M. et al.
10.Distinct Immune cell populations define response article distinct immune cell populations define response to anti-PD-1 monotherapy and anti-PD-1 / anti-CTLA-4 combined therapy. Cancer Cell, 2019.
11.Bottcher, C. et al. Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry. Nat. Neurosci., 2019.
12.Wang, J. et al. Fibrinogen-like Protein 1 Is a Major Immune Article Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell, 2018.
13.Sibener LV, et al. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 2018.
14.Roy Chowdhury R, et al. A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes. Nature, 2018.
15.Cheung P, et al. Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging. Cell, 2018.
质谱流式技术应用
